Prevention of sea-sickness, do consult your doctor about these choices.
| Preference Rank | Medicine (Brand/Generic) | Active Ingredient | Effectiveness for Sea Sickness | Mechanism / Action | Common Side Effects | Serious / Rare Side Effects | How to Use | Notes / Cautions |
|---|---|---|---|---|---|---|---|---|
| 🥇 1. Scopolamine Patch (Transderm-Scop, Scopoderm) | Hyoscine hydrobromide / Scopolamine | 🏆 Most effective — prevents sea sickness for long durations (up to 72 hrs) | Antimuscarinic — blocks vestibular nerve signals to vomiting center | Dry mouth, drowsiness, blurred vision | Confusion, urinary retention, dilated pupils (if touched eyes after handling patch) | Apply one patch behind ear 4 hrs before travel; lasts 72 hrs; replace every 3 days if needed | Avoid touching eyes after applying; caution in elderly, glaucoma, prostate issues. Prescription-only in many countries. | |
| 🥈 2. Digilan / Avomin | Meclizine 25 mg | ✅ Highly effective, long-acting (8–12 hrs) | Antihistamine (H₁ blocker) + mild anticholinergic | Drowsiness, dry mouth, blurred vision | Rare confusion (elderly), urinary retention | Take 1 tablet (25 mg) 1 hour before travel, repeat every 8–12 hrs if needed | Widely used; safe for most adults; avoid alcohol and driving. | |
| 🥉 3. Stemetil | Prochlorperazine | Moderate–high — for severe nausea or vertigo | Dopamine (D₂) blocker (CNS-acting) | Drowsiness, dry mouth, restlessness | Muscle stiffness, tremor, rare movement disorders | Take 5–10 mg tablet up to 3 times daily or as prescribed | Effective but more side effects; avoid prolonged use or in elderly. | |
| 4️⃣ 4. Ondem-4 | Ondansetron 4 mg | Moderate — helps nausea/vomiting but not preventive for motion sickness | 5-HT₃ receptor blocker | Headache, constipation, fatigue | QT prolongation, allergic reactions (rare) | Take 4 mg tablet 30 minutes before travel | Best for nausea from illness, not pure motion sickness. | |
| 5️⃣ 5. Perinom | Domperidone 10 mg | Low — limited effect on motion sickness | Peripheral Dopamine (D₂) blocker (increases gut motility) | Dry mouth, headache, abdominal cramps | QT prolongation, rare arrhythmia | Take 10 mg before meals or before travel | Not effective for vestibular-type nausea; cardiac caution required. |




