Prevention of Sea-sickness

 Prevention of sea-sickness, do consult your doctor about these choices.

Preference Rank	Medicine (Brand/Generic)	Active Ingredient	Effectiveness for Sea Sickness	Mechanism / Action	Common Side Effects	Serious / Rare Side Effects	How to Use	Notes / Cautions
🥇 1. Scopolamine Patch (Transderm-Scop, Scopoderm)	Hyoscine hydrobromide / Scopolamine	🏆 Most effective — prevents sea sickness for long durations (up to 72 hrs)	Antimuscarinic — blocks vestibular nerve signals to vomiting center	Dry mouth, drowsiness, blurred vision	Confusion, urinary retention, dilated pupils (if touched eyes after handling patch)	Apply one patch behind ear 4 hrs before travel; lasts 72 hrs; replace every 3 days if needed	Avoid touching eyes after applying; caution in elderly, glaucoma, prostate issues. Prescription-only in many countries.
🥈 2. Digilan / Avomin	Meclizine 25 mg	✅ Highly effective, long-acting (8–12 hrs)	Antihistamine (H₁ blocker) + mild anticholinergic	Drowsiness, dry mouth, blurred vision	Rare confusion (elderly), urinary retention	Take 1 tablet (25 mg) 1 hour before travel, repeat every 8–12 hrs if needed	Widely used; safe for most adults; avoid alcohol and driving.
🥉 3. Stemetil	Prochlorperazine	Moderate–high — for severe nausea or vertigo	Dopamine (D₂) blocker (CNS-acting)	Drowsiness, dry mouth, restlessness	Muscle stiffness, tremor, rare movement disorders	Take 5–10 mg tablet up to 3 times daily or as prescribed	Effective but more side effects; avoid prolonged use or in elderly.
4️⃣ 4. Ondem-4	Ondansetron 4 mg	Moderate — helps nausea/vomiting but not preventive for motion sickness	5-HT₃ receptor blocker	Headache, constipation, fatigue	QT prolongation, allergic reactions (rare)	Take 4 mg tablet 30 minutes before travel	Best for nausea from illness, not pure motion sickness.
5️⃣ 5. Perinom	Domperidone 10 mg	Low — limited effect on motion sickness	Peripheral Dopamine (D₂) blocker (increases gut motility)	Dry mouth, headache, abdominal cramps	QT prolongation, rare arrhythmia	Take 10 mg before meals or before travel	Not effective for vestibular-type nausea; cardiac caution required.